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帕拉米韦

Tier C — Watch / trade

Peramivir Hydrate

Biocryst Pharmaceuticals Inc
Originator
2010
First approval
-
Expiry (public)
$0.03B ▲
Peak sales
化学药
Type

Targets：NA

Brand：Rapiacta、Peramiflu、Enpiflu Premix、力纬、Alpivab、Rapivab

Indications (approved)：流感病毒感染

Regional status

US
批准上市
2014-12-19
EU
撤市
China
批准上市
2013-04-05
Japan
批准上市
2010-01-13

Synthetic routes & intermediates5 routes

Originator routes × 2Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 1.22 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
PERA-00179200-56-9(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-002138923-03-2methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate
PERA-003168683-02-1Availablemethyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-0047796-76-13-(nitromethyl)pentane
PERA-005229613-93-8Availablemethyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-006316173-29-2methyl (1S,2S,3S,4R)-3-((S)-1-amino-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-007229614-05-5methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-008229615-05-8methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-amino-2-hydroxycyclopentane-1-carboxylate
PERA-0094023-02-31H-pyrazole-1-carboximidamide hydrochloride
OriginatorRoute 5Steps 5 · Total yield 500 mg
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
PERA-014419563-22-7methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate
PERA-01591400-03-2(Z)-2-ethyl-N-hydroxybutanimidoyl chloride
PERA-019-methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylate
PERA-020-(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylic acid
PERA-021152120-54-2(3R,3'R)-di-tert-butyl 3,3'-((((pyrimidine-4,6-dicarbonyl)bis(azanediyl))bis(2-(5-aminopentanamido)-4-(trifluoromethyl)-6,1-phenylene))bis(oxy))bis(pyrrolidine-1-carboxylate)
PERA-022-methyl (1S,4R)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)cyclopent-2-ene-1-carboxylate
PERA-023-methyl (3aR,4R,6S,6aS)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
OptimisedRoute 2Steps 7 · Total yield 0.91 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
PERA-00179200-56-9(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-002138923-03-2methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate
PERA-003168683-02-1Availablemethyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-005229613-93-8Availablemethyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-006316173-29-2methyl (1S,2S,3S,4R)-3-((S)-1-amino-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-007229614-05-5methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-0105399-18-8(E)-2-ethylbutanal oxime
PERA-011229614-17-9methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-amino-2-hydroxycyclopentane-1-carboxylate hydrochloride
PERA-01229671-92-9carbamimidic chloride hydrochloride
OptimisedRoute 3Steps 6 · Total yield 49.8 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
PERA-003168683-02-1Availablemethyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-005229613-93-8Availablemethyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-01349805-30-32-azabicyclo[2.2.1]hept-5-en-3-one
PERA-014419563-22-7methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate
PERA-01591400-03-2(Z)-2-ethyl-N-hydroxybutanimidoyl chloride
PERA-016316173-27-0(3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylic acid
PERA-017-methyl (1S,2S,3S,4R)-3-((S)-1-aminoethyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
OptimisedRoute 4Steps 7 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
PERA-00179200-56-9(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-003168683-02-1Availablemethyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-0047796-76-13-(nitromethyl)pentane
PERA-005229613-93-8Availablemethyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-007229614-05-5methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-008229615-05-8methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-amino-2-hydroxycyclopentane-1-carboxylate
PERA-018107819-90-9 tert-butyl N-[[(2-methylpropan-2-yl)oxycarbonylamino]-methylsulfanylmethylidene]carbamate
PERA-019-methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylate
PERA-020-(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylic acid

Frequently asked questions

What are the approved indications of Peramivir Hydrate?

Approved indications include: 流感病毒感染.

When does the Peramivir Hydrate patent expire?

No public expiry year is available for Peramivir Hydrate yet; this page updates once verified.

How many synthesis routes are recorded for Peramivir Hydrate?

5 synthesis routes are recorded; the shortest is 5 steps with 500 mg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Peramivir Hydrate intermediates?

2 intermediate CAS of Peramivir Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Peramivir Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24