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CAS 91400-03-2
(Z)-2-ethyl-N-hydroxybutanimidoyl chloride
Codes：PERA-015
Application context (from source-drug indications)
流感病毒感染帕拉米韦甲型流感病毒感染帕拉米韦乙型流感病毒感染帕拉米韦鼻塞帕拉米韦发热帕拉米韦咳嗽帕拉米韦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 帕拉米韦Peramivir Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate→methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate→2-azabicyclo[2.2.1]hept-5-en-3-one→methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate→(Z)-2-ethyl-N-hydroxybutanimidoyl chloride→(3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylic acid→methyl (1S,2S,3S,4R)-3-((S)-1-aminoethyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate→(Z)-2-ethyl-N-hydroxybutanimidoyl chloride→methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylate→(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylic acid→(3R,3'R)-di-tert-butyl 3,3'-((((pyrimidine-4,6-dicarbonyl)bis(azanediyl))bis(2-(5-aminopentanamido)-4-(trifluoromethyl)-6,1-phenylene))bis(oxy))bis(pyrrolidine-1-carboxylate)→methyl (1S,4R)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)cyclopent-2-ene-1-carboxylate→methyl (3aR,4R,6S,6aS)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
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