CAS 99-06-9

3-Carboxyphenol

Codes：(XXVIII)638294-1-d、(IX)409139-1-a

Application context (from source-drug indications)

收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
非奈利酮Finerenone	Tier C — Watch / trade	2030
氯苯唑酸葡甲胺Tafamidis Meglumine	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

非奈利酮优化路线steps: 4total yield: /

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

氯苯唑酸葡甲胺优化路线steps: 7total yield: /

3,5-Dichlorobenzoic acid→3,5-Dichloro-1-benzenecarbonyl chloride→(4-Carboxy-2-hydroxyphenyl)amine→2-Bromo-4-methoxycarbonylaniline→2-Hydroxy-4-methoxycarbonylaniline→4-Amino-3-hydroxybenzoic acid methyl ester hydrochloride→4-(3,5-Dichlorobenzamido)-3-hydroxybenzoic acid→Methyl 3-bromo-4-(3,5-dichlorobenzamido)benzoate→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Methyl 1,3-benzoxazole-6-carboxylate→1,3-Bis(chloranyl)benzene→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→3-Carboxyphenol→3-Carboxy-6-nitrophenol

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—

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