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CAS 1395964-06-3
methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester
Codes：TAFA-005、(V)409139-1-a、(IIIa)409139-8-a、(V)409139-10-a
Application context (from source-drug indications)
淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 氯苯唑酸葡甲胺Tafamidis Meglumine | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-amino-3-hydroxybenzoic acid→3,5-dichlorobenzoyl chloride→4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid→2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate
methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate→methyl benzo[d]oxazole-6-carboxylate→(3,5-dichlorophenyl)(mesityl)iodonium trifluoromethanesulfonate
3,5-Dichlorobenzoic acid→3,5-Dichloro-1-benzenecarbonyl chloride→(4-Carboxy-2-hydroxyphenyl)amine→2-Bromo-4-methoxycarbonylaniline→2-Hydroxy-4-methoxycarbonylaniline→4-Amino-3-hydroxybenzoic acid methyl ester hydrochloride→4-(3,5-Dichlorobenzamido)-3-hydroxybenzoic acid→Methyl 3-bromo-4-(3,5-dichlorobenzamido)benzoate→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Methyl 1,3-benzoxazole-6-carboxylate→1,3-Bis(chloranyl)benzene→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→3-Carboxyphenol→3-Carboxy-6-nitrophenol
2-Hydroxy-4-methoxycarbonylaniline→Butyl 4-amino-3-hydroxybenzoate→tert-Butyl 4-amino-3-hydroxybenzoate→Phenyl 4-amino-3-hydroxybenzoate→3,5-Dichlorobenzaldehyde→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→tert-Butyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate→Phenyl 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylate
(4-Carboxy-2-hydroxyphenyl)amine→2-Hydroxy-4-methoxycarbonylaniline→3,5-Dichlorobenzoic acid→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid
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