CAS 2905-62-6

3,5-Dichloro-1-benzenecarbonyl chloride3,5-dichlorobenzoyl chloride

Codes：(I)409139-3-a、(I)409139-4-a、TAFA-002、(II)409139-1-a

Application context (from source-drug indications)

转甲状腺素运载蛋白淀粉样变性氯苯唑酸心脏病氯苯唑酸淀粉样多神经病氯苯唑酸葡甲胺转甲状腺素运载蛋白淀粉样变性氯苯唑酸葡甲胺淀粉样变氯苯唑酸葡甲胺心肌疾病氯苯唑酸葡甲胺淀粉体轻链淀粉样变性氯苯唑酸葡甲胺家族性淀粉样神经病氯苯唑酸葡甲胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
氯苯唑酸Tafamidis	Tier C — Watch / trade	-
氯苯唑酸葡甲胺Tafamidis Meglumine	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

氯苯唑酸优化路线steps: 4total yield: /

3,5-Dichloro-1-benzenecarbonyl chloride→3,5-Dichloro-N-methyl-N-phenylbenzamide→N-[(3,5-Dichlorophenyl)(methoxy)methylidene]-N-methylbenzeniminium trifluoromethanesulfonate→1,3-Dichloro-5-(trimethoxymethyl)benzene→2-(Hydroxymethyl)-2-phenylpropane-1,3-diol→2-Phenylacetaldehyde→2-Ethyl-2-(hydroxymethyl)propane-1,3-diol→1-(3,5-Dichlorophenyl)-4-phenyl-2,6,7-trioxabicyclo[2.2.2]octane→1-(3,5-Dichlorophenyl)-4-ethyl-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid

氯苯唑酸优化路线steps: 3total yield: /

3,5-Dichloro-1-benzenecarbonyl chloride→(3-Methyloxetan-3-yl)methanol→(3-Methyloxetan-3-yl)methyl 3,5-dichlorobenzoate→1-(3,5-Dichlorophenyl)-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane→(4-Carboxy-2-hydroxyphenyl)amine→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid

氯苯唑酸葡甲胺原研路线steps: 5total yield: 3.35 g

4-amino-3-hydroxybenzoic acid→3,5-dichlorobenzoyl chloride→4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid→2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→methyl 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate

氯苯唑酸葡甲胺优化路线steps: 7total yield: /

3,5-Dichlorobenzoic acid→3,5-Dichloro-1-benzenecarbonyl chloride→(4-Carboxy-2-hydroxyphenyl)amine→2-Bromo-4-methoxycarbonylaniline→2-Hydroxy-4-methoxycarbonylaniline→4-Amino-3-hydroxybenzoic acid methyl ester hydrochloride→4-(3,5-Dichlorobenzamido)-3-hydroxybenzoic acid→Methyl 3-bromo-4-(3,5-dichlorobenzamido)benzoate→Methyl 4-(3,5-dichlorobenzamido)-3-hydroxybenzoate→2-(3,5-Dichlorophenyl)benzoxazole-6-carboxylic acid methyl ester→Methyl 1,3-benzoxazole-6-carboxylate→1,3-Bis(chloranyl)benzene→2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carboxylic acid→3-Carboxyphenol→3-Carboxy-6-nitrophenol

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