CAS 74-88-4

Iodomethaneiodomethane-11CMethyl iodide

登记编号：(I)270899-4-a、LACO-011、(XXXIV)638294-1-d、Ephedrine Sulfate-019、Desvenlafaxine-024

应用背景（按来源药适应症）

重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮强直阵挛性癫痫拉考沙胺癫痫拉考沙胺癫痫部分性发作拉考沙胺癫痫发作拉考沙胺收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮低血压硫酸麻黄碱重度抑郁症地文拉法辛抑郁症地文拉法辛

来源药（使用该中间体的合成路线）

品种	梯队	到期年
盐酸艾司氯胺酮Esketamine Hydrochloride	Tier B · 提前布局	2029
拉考沙胺Lacosamide	Tier B · 提前布局	2028
非奈利酮Finerenone	Tier C · 观察 / 贸易	2030
硫酸麻黄碱Ephedrine Sulfate	Tier C · 观察 / 贸易	-
地文拉法辛Desvenlafaxine	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

盐酸艾司氯胺酮优化路线步数：6总收率：/

Iodomethane→Chlorocyclopentane→1-Chloro-2-cyanobenzene→(2-Chlorophenyl)(cyclopentyl)methanone→2-Chlorobenzoyl chloride→Cyclopentene→(1-Bromocyclopentyl)(2-chlorophenyl) ketone→Aminomethane→1-[(E)-(2-Chlorophenyl)(methylimino)methyl]cyclopentan-1-ol hydrogen chloride→(±)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride→2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

拉考沙胺优化路线步数：4总收率：10.5 g

(tert-butoxycarbonyl)-D-serine→iodomethane-11C→N-(tert-butoxycarbonyl)-O-methyl-D-serine→O-methyl-D-serine→N-acetyl-O-methyl-D-serine

非奈利酮优化路线步数：4总收率：/

2-Methoxy-4-cyanobenzaldehyde→3-Methoxy-4-methylbenzonitrile→3-Carboxyphenol→3-Hydroxybenzamide→3-Cyanophenol→Formaldehyde→4-Cyano-2-hydroxybenzaldehyde→Dimethoxysulfone→Iodomethane→2-Fluoro-4-cyanotoluene→Hydroxymethane→4-Bromo-3-methoxybenzamide→2-Methoxy-4-cyanobromobenzene

硫酸麻黄碱优化路线步数：9总收率：/

Cinnamyl alcohol→(±)-3-(Benzyloxy)-2-bromo-3-phenylpropan-1-ol→(±)-2-[(Benzyloxy)(phenyl)methyl]oxirane→(2R)-2-[(R)-(Benzyloxy)(phenyl)methyl]oxirane→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-ol→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-yl methanesulfonate→[(1R,2S)-2-Azido-1-(benzyloxy)propyl]benzene→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]carbamate→Methyl iodide→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]methylcarbamate→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol

地文拉法辛优化路线步数：10总收率：82.4g(Desvenlafaxine succinate (API))

2-(4-Hydroxyphenyl)acetonitrile→Cyclohexanone→(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile→4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol→2-[4-(Oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl]acetonitrile→2-(1-Hydroxycyclohexyl)-2-[4-(oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl](1-hydroxycyclohexyl)acetonitrile→Iodomethane→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。