Metabolic & GLP-1
38 patent-cliff drugs in Metabolic & GLP-1 (classified by indication keywords and explicit molecule lists from our structured data), 19 with recorded synthesis routes and 13 with on-sale intermediates. Every "Available" badge links to real listings for RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| 非奈利酮 Finerenone | C · Watch | 2030 | 收缩性心力衰竭、舒张期心力衰竭、心脏衰竭 | 35 | 96 | Available ×96 |
| 艾托格列净 Ertugliflozin | C · Watch | - | 二型糖尿病 | 4 | 48 | Available ×48 |
| 恩格列净 Empagliflozin | A · Act now | 2028 | 慢性肾功能不全、心脏衰竭、二型糖尿病 | 3 | 24 | Available ×24 |
| 利格列汀 Linagliptin | C · Watch | 2029 | 二型糖尿病 | 4 | 21 | Available ×21 |
| 利非司特 Lifitegrast | C · Watch | - | 干眼症、干眼综合征 | 1 | 20 | Available ×20 |
| 苯磺酸美洛加巴林 Mirogabalin besilate | C · Watch | 2030 | 糖尿病神经病变、疱疹后神经痛、周围神经系统疾病 | 2 | 14 | Available ×14 |
| 索格列净 Sotagliflozin | C · Watch | 2032 | 二型糖尿病、慢性肾功能不全、心脏衰竭 | 1 | 14 | Available ×14 |
| 盐酸替那帕诺 Tenapanor hydrochloride | C · Watch | - | 高磷血症、慢性肾功能不全、便秘 | 1 | 10 | Available ×10 |
| 苯甲酸阿格列汀 Alogliptin Benzoate | C · Watch | - | 二型糖尿病 | 4 | 24 | Available ×9 |
| 维格列汀 Vildagliptin | B · Position early | - | 二型糖尿病 | 6 | 25 | Available ×3 |
| 琥珀酸曲格列汀 Trelagliptin Succinate | C · Watch | - | 二型糖尿病 | 3 | 16 | Available ×3 |
| 替尔泊肽 Tirzepatide | B · Position early | 2036 | 阻塞性睡眠呼吸暂停综合征、肥胖症、超重 | 9 | 1 | Available ×1 |
| 琥珀酸去甲文拉法辛 Desvenlafaxine Succinate Hydrate | C · Watch | - | 抑郁症、重度抑郁症 | 6 | 22 | Available ×1 |
| 阿齐沙坦 Azilsartan | C · Watch | - | 高血压 | 6 | 20 | - |
| Bremelanotide Bremelanotide | C · Watch | - | 心理性性功能障碍 | 4 | 1 | - |
| 托匹司他 Topiroxostat | C · Watch | - | 高尿酸血症、痛风 | 4 | 13 | - |
| 赛利司他 Cetilistat | C · Watch | - | 肥胖症 | 3 | 9 | - |
| 聚乙二醇洛塞那肽 PEG-Loxenatide | C · Watch | - | 二型糖尿病 | 1 | 2 | - |
| 洛贝格列酮硫酸盐 Lobeglitazone Sulfate | C · Watch | - | 二型糖尿病 | 1 | 9 | - |
| 达格列净丙二醇/盐酸二甲双胍 Dapagliflozin Propanediol/Metformin Hydrochloride | A · Act now | 2030 | 二型糖尿病 | - | - | - |
| 卡格列净/盐酸二甲双胍 Canagliflozin/Metformin Hydrochloride | B · Position early | 2029 | 终末期肾脏病、心脏和血管疾病、腹主动脉瘤 | - | - | - |
| 鼻用高血糖素 Glucagon intranasal (Eli Lilly/Locemia Solutions) | C · Watch | - | 低血糖症 | - | - | - |
| 阿托伐他汀钙/盐酸二甲双胍 Atorvastatin Calcium Hydrate/Metformin Hydrochloride | C · Watch | - | 二型糖尿病、高脂血症 | - | - | - |
| 磷酸西格列汀一水合物/伊格列净L-脯氨酸盐 Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | C · Watch | - | 二型糖尿病 | - | - | - |
| 血管紧张素II Angiotensin II | C · Watch | - | 低血压、休克 | - | - | - |
| Sitagliptin/Ertugliflozin Sitagliptin/Ertugliflozin | C · Watch | - | 二型糖尿病 | - | - | - |
| 盐酸二甲双胍/艾托格列净 Metformin Hydrochloride/Ertugliflozin | C · Watch | - | 二型糖尿病 | - | - | - |
| 异麦芽糖酐铁 Iron Isomaltoside | C · Watch | - | 缺铁性贫血 | - | - | - |
| 达格列净丙二醇一水化物/盐酸沙格列汀 Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | C · Watch | - | 二型糖尿病 | - | - | - |
| 利格列汀/恩格列净 Linagliptin/Empagliflozin | C · Watch | - | 心脏和血管疾病、二型糖尿病 | - | - | - |
| 吉格列汀酒石酸盐/盐酸二甲双胍 Gemigliptin L-tartrate Sesquihydrate/Metformin Hydrochloride | C · Watch | - | 二型糖尿病 | - | - | - |
| 醋酸二甲双胍 Metformin acetate | C · Watch | - | 肥胖症、糖尿病 | - | - | - |
| 利格列汀/盐酸二甲双胍 Linagliptin/Metformin Hydrochloride | B · Position early | - | 二型糖尿病 | - | - | - |
| 苯甲酸阿格列汀/盐酸吡格列酮 Alogliptin Benzoate/Pioglitazone Hydrochloride | C · Watch | - | 二型糖尿病 | - | - | - |
| 酒石酸罗格列酮 Rosilitazone Tartrate | C · Watch | - | 二型糖尿病 | - | - | - |
| 氢溴酸安非他酮 Bupropion hydrobromide | C · Watch | - | 季节性情感障碍、重度抑郁症 | - | - | - |
| 维格列汀/盐酸二甲双胍 Vildagliptin/Metformin Hydrochloride | C · Watch | - | 二型糖尿病 | - | - | - |
| 司美格鲁肽 Semaglutide | A · Act now | 2031 | 超重、肥胖症、二型糖尿病 | - | - | - |
Frequently asked questions
Which patent-cliff drugs in Metabolic & GLP-1 are worth tracking?
38 drugs related to Metabolic & GLP-1 are tracked on this site, 19 of them with recorded synthesis routes. See the table above and open each drug profile for routes and intermediates.
Where can I source Metabolic & GLP-1 intermediates?
Key intermediates of 13 drugs in this table are available through the Unibest supply network; for the rest, submit an RFQ per CAS on the intermediate profile pages.
Where can I check patent expiry for these drugs?
Each drug profile shows the public expiry year; yearly overviews are available at /patent-cliff/expires/<year>.
Source: cross-verified structured fields · Classification: indication keywords + explicit molecule lists · 2026-09-24