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Oncology & Hematology
77 · drugs62 · with routes45 · with on-sale intermediates
77 patent-cliff drugs in Oncology & Hematology (classified by indication keywords and explicit molecule lists from our structured data), 62 with recorded synthesis routes and 45 with on-sale intermediates. Every "Available" badge links to real listings for RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| 哌柏西利 Palbociclib | A · Act now | 2027 | 乳腺癌 | 5 | 52 | Available ×52 |
| 阿尼芬净 Anidulafungin | C · Watch | - | 念珠菌病、念珠菌血症 | 11 | 41 | Available ×41 |
| 阿昔替尼 Axitinib | B · Position early | - | 肾细胞癌 | 5 | 31 | Available ×31 |
| 阿来替尼盐酸盐 Alectinib Hydrochloride | B · Position early | 2030 | 非小细胞肺癌、肺癌 | 3 | 30 | Available ×30 |
| 克唑替尼 Crizotinib | C · Watch | - | 原发性皮肤间变性大细胞淋巴瘤、间变大细胞淋巴瘤、非小细胞肺癌 | 5 | 29 | Available ×29 |
| 甲磺酸奥希替尼 Osimertinib Mesylate | A · Act now | 2031 | 非小细胞肺癌 | 4 | 29 | Available ×29 |
| 苹果酸舒尼替尼 Sunitinib Malate | B · Position early | - | 胰腺神经内分泌肿瘤、肾细胞癌、胃肠道间质瘤 | 5 | 27 | Available ×27 |
| 乙磺酸尼达尼布 Nintedanib Esylate | B · Position early | - | 系统性硬化相关肺间质疾病、特发性肺纤维化、非小细胞肺癌 | 4 | 25 | Available ×25 |
| 非布司他 Febuxostat | C · Watch | - | 高尿酸血症、痛风 | 4 | 25 | Available ×25 |
| 苹果酸卡博替尼 Cabozantinib S-malate | B · Position early | 2029 | 神经内分泌瘤、胰腺神经内分泌肿瘤、肾细胞癌 | 3 | 21 | Available ×21 |
| 阿帕他胺 Apalutamide | A · Act now | 2030 | 去势抵抗性前列腺肿瘤、前列腺癌 | 2 | 20 | Available ×20 |
| 甲磺酸仑伐替尼 Lenvatinib Mesilate | A · Act now | 2028 | 肾细胞癌、子宫内膜癌、肝细胞癌 | 3 | 18 | Available ×18 |
| 盐酸卡马替尼 Capmatinib Hydrochloride | C · Watch | 2032 | 非小细胞肺癌 | 1 | 16 | Available ×16 |
| 阿贝西利 Abemaciclib | A · Act now | 2029 | 乳腺癌 | 2 | 15 | Available ×15 |
| 琥珀酸瑞波西利 Ribociclib Succinate | A · Act now | 2029 | 乳腺癌 | 1 | 14 | Available ×14 |
| 恩曲替尼 Entrectinib | C · Watch | 2030 | 实体瘤、非小细胞肺癌 | 1 | 14 | Available ×14 |
| 奥拉帕利 Olaparib | A · Act now | 2028 | 子宫内膜癌、去势抵抗性前列腺肿瘤、前列腺癌 | 2 | 13 | Available ×13 |
| 甲磺酸达拉非尼 Dabrafenib Mesylate | B · Position early | 2029 | 甲状腺瘤、结直肠癌、胶质瘤 | 2 | 12 | Available ×12 |
| 瑞卢戈利 Relugolix | C · Watch | 2031 | 前列腺癌、平滑肌瘤 | 1 | 12 | Available ×12 |
| 图卡替尼 Tucatinib | C · Watch | 2030 | 乳腺癌、结直肠癌 | 1 | 10 | Available ×10 |
| 达罗他胺 Darolutamide | B · Position early | 2031 | 激素敏感性前列腺肿瘤、去势敏感性前列腺肿瘤、前列腺癌 | 1 | 9 | Available ×9 |
| 盐酸培唑帕尼 Pazopanib Hydrochloride | C · Watch | - | 肾细胞癌、肉瘤、软组织肿瘤 | 1 | 9 | Available ×9 |
| 曲美替尼 Trametinib | C · Watch | 2029 | 甲状腺瘤、胶质瘤、毛细胞白血病 | 1 | 13 | Available ×6 |
| 伊沙匹隆 Ixabepilone | C · Watch | - | 乳腺癌 | 5 | 84 | Available ×5 |
| 马来酸阿法替尼 Afatinib Dimaleate | C · Watch | - | 非小细胞肺癌 | 4 | 33 | Available ×4 |
| 普拉替尼 Pralsetinib | C · Watch | 2031 | 非小细胞肺癌、甲状腺瘤、甲状腺髓样癌 | 7 | 41 | Available ×3 |
| 马来酸奈拉替尼 Neratinib Maleate | C · Watch | 2030 | 乳腺癌 | 4 | 30 | Available ×3 |
| 盐酸埃克替尼 Icotinib Hydrochloride | C · Watch | - | 非小细胞肺癌 | 4 | 23 | Available ×3 |
| 塞普替尼 Selpercatinib | C · Watch | 2032 | 实体瘤、甲状腺髓样癌、非小细胞肺癌 | 3 | 26 | Available ×3 |
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals) Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | C · Watch | - | 膀胱癌、头颈癌 | 37 | 156 | Available ×2 |
| 甲苯磺酸索拉非尼 Sorafenib Tosylate | B · Position early | - | 甲状腺瘤、肝细胞癌、肾细胞癌 | 5 | 14 | Available ×2 |
| 维莫地吉 Vismodegib | C · Watch | - | 基底细胞癌 | 3 | 15 | Available ×2 |
| 芦卡帕利 Rucaparib Camsylate | C · Watch | - | 前列腺癌、腹膜癌、卵巢上皮癌 | 2 | 25 | Available ×2 |
| 恩考芬尼 Encorafenib | C · Watch | 2030 | 非小细胞肺癌、结直肠癌、甲状腺瘤 | 1 | 23 | Available ×2 |
| 普拉曲沙 Pralatrexate | C · Watch | - | 外周T细胞淋巴瘤 | 5 | 31 | Available ×1 |
| 恩扎卢胺 Enzalutamide | A · Act now | 2027 | 激素敏感性前列腺肿瘤、去势抵抗性前列腺肿瘤、前列腺癌 | 4 | 15 | Available ×1 |
| 厄达替尼 Erdafitinib | C · Watch | 2030 | 尿路上皮癌、泌尿系肿瘤 | 3 | 18 | Available ×1 |
| 考比司他 Cobicistat | C · Watch | - | HIV感染 | 3 | 36 | Available ×1 |
| 门冬氨酸帕瑞肽 Pasireotide Diaspartate | C · Watch | - | 库欣综合征、垂体ACTH分泌过多 | 3 | 9 | Available ×1 |
| 佩米替尼 Pemigatinib | C · Watch | 2032 | 骨髓瘤、淋巴瘤、胆管癌 | 2 | 28 | Available ×1 |
| 阿吡利塞 Alpelisib | C · Watch | 2029 | 生长障碍、遗传病、PIK3CA相关生长过度谱系 | 2 | 17 | Available ×1 |
| 贝美替尼 Binimetinib | C · Watch | - | 非小细胞肺癌、黑色素瘤 | 2 | 20 | Available ×1 |
| 奥莫替尼 Olmutinib | C · Watch | - | 非小细胞肺癌 | 2 | 12 | Available ×1 |
| 西达本胺 Chidamide | C · Watch | - | 弥漫性大B-细胞淋巴瘤、T-细胞白血病、乳腺癌 | 1 | 6 | Available ×1 |
| 甲磺酸阿帕替尼 Apatinib Mesylate | C · Watch | - | 乳腺癌、胃癌 | 1 | 6 | Available ×1 |
| 罗米地辛 Romidepsin | C · Watch | - | 外周T细胞淋巴瘤、淋巴瘤 | 5 | 36 | - |
| 米铂水合物 Miriplatin Hydrate | C · Watch | - | 肝细胞癌 | 5 | 8 | - |
| 溴化甲基纳曲酮 Methylnaltrexone Bromide | C · Watch | - | 阿片类依赖、便秘、阿片类药物引起的便秘 | 5 | 13 | - |
| 芦比前列酮 Lubiprostone | C · Watch | - | 便秘、阿片类药物引起的便秘、慢性特发性便秘 | 5 | 48 | - |
| 普拉睾酮 Prasterone | C · Watch | - | 外阴阴道萎缩、萎缩、性交困难 | 4 | 11 | - |
| 酒石酸长春氟宁 Vinflunine Ditartrate | C · Watch | - | 泌尿系肿瘤、尿路上皮癌 | 3 | 10 | - |
| 地西他滨 Decitabine | C · Watch | - | 过敏反应、睫状肌麻痹、低血压 | 3 | 12 | - |
| 洛拉替尼 Lorlatinib | B · Position early | 2030 | 非小细胞肺癌 | 2 | 20 | - |
| 乳酸帕比司他 Panobinostat Lactate | C · Watch | - | 多发性骨髓瘤 | 2 | 11 | - |
| 氟[18F]美他酚 Flutemetamol (18F) | C · Watch | - | 造影检查、阿尔茨海默病、认知障碍 | 2 | 13 | - |
| 地拉罗司 Deferasirox | B · Position early | - | 地中海贫血、铁超负荷、β-地中海贫血 | 2 | 8 | - |
| Fedratinib Fedratinib | C · Watch | - | 骨髓纤维化、脾大 | 1 | 4 | - |
| 吡昔替尼 Pexidartinib | C · Watch | - | 腱鞘巨细胞瘤 | 1 | 7 | - |
| 盐酸安罗替尼 Anlotinib Dihydrochloride | C · Watch | - | 肺泡软组织肉瘤、肝细胞癌、子宫内膜癌 | 1 | 13 | - |
| 依伏卡塞 Evocalcet | C · Watch | - | 继发性甲状旁腺功能亢进症 | 1 | 8 | - |
| Ga-68 Edotreotide Ga-68 Edotreotide | C · Watch | - | 神经内分泌瘤、胰腺神经内分泌肿瘤、诊断剂 | 1 | 1 | - |
| 地塞米松培酯 Dexamethasone Cipecilate | C · Watch | - | 过敏性鼻炎 | 1 | 4 | - |
| Paclitaxel/Encequidar mesylate Paclitaxel/Encequidar mesylate | C · Watch | - | 乳腺癌、腺癌 | - | - | - |
| 可利霉素 Carrimycin | C · Watch | - | 细菌感染 | - | - | - |
| 血管紧张素II Angiotensin II | C · Watch | - | 低血压、休克 | - | - | - |
| 异麦芽糖酐铁 Iron Isomaltoside | C · Watch | - | 缺铁性贫血 | - | - | - |
| 海姆泊芬 Hemoporfin | C · Watch | - | 肿瘤 | - | - | - |
| Paclitaxel Oral Solution (DAE HWA Pharmaceutical) Paclitaxel Oral Solution (DAE HWA Pharmaceutical) | C · Watch | - | 胃癌 | - | - | - |
| （68镓）镓氧奥曲肽 Gallium (68Ga) oxodotreotide | C · Watch | - | 神经内分泌瘤 | - | - | - |
| Fluciclovine F 18 Fluciclovine F 18 | C · Watch | - | 前列腺癌、诊断剂 | - | - | - |
| 阿法诺肽 Afamelanotide | C · Watch | - | 红细胞生成性原卟啉症 | - | - | - |
| 双羟萘酸帕瑞肽 Pasireotide Pamoate | C · Watch | - | 肢端肥大症、库欣综合征、垂体ACTH分泌过多 | - | - | - |
| 结合雌激素/醋酸巴多昔芬 Conjugated Estrogens/Bazedoxifene Acetate | C · Watch | - | 雌激素缺乏综合征、骨质疏松症、血管舒缩症 | - | - | - |
| 醋酸二甲双胍 Metformin acetate | C · Watch | - | 肥胖症、糖尿病 | - | - | - |
| 布比卡因脂质体 Liposomal bupivacaine | C · Watch | - | 疼痛、术后疼痛 | - | - | - |
| 氟化钠（F18） Sodium Fluoride F-18 | C · Watch | - | 骨转移、造影检查 | - | - | - |
| 盐酸纳洛酮/盐酸羟考酮 Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate | C · Watch | - | 疼痛、不宁腿综合征 | - | - | - |
Frequently asked questions
Which patent-cliff drugs in Oncology & Hematology are worth tracking?
77 drugs related to Oncology & Hematology are tracked on this site, 62 of them with recorded synthesis routes. See the table above and open each drug profile for routes and intermediates.
Where can I source Oncology & Hematology intermediates?
Key intermediates of 45 drugs in this table are available through the Unibest supply network; for the rest, submit an RFQ per CAS on the intermediate profile pages.
Where can I check patent expiry for these drugs?
Each drug profile shows the public expiry year; yearly overviews are available at /patent-cliff/expires/<year>.
Source: cross-verified structured fields · Classification: indication keywords + explicit molecule lists · 2026-09-24